Investigation of the in vitro and in vivo effects of new
microneurotrophins (MNTs) on neuronal cells.
The position concerns workpackages (WP) and of the project
DINNESMIN - Development of Innovative Neuroprotective Neurogenerative
Synthetic MicroNeurotrophins. Specifically, the candidate will be
involved in the investigation of the chemical affinity of the new MNTs
with the TrkA, TrkB and p75NTR receptors as well as the activation of
cellular signaling pathways and neuronal survival / apoptosis in primary
hippocampal neuronal cultures of wt and transgenic 5xFAD mice (WP .
The candidate will also perform in vivo studies on the
neuroregenerative activity of MNTs in adult hippocampal neurogenesis of
the 5xFAD mice (WP