University of Crete
Heraklion, Greece
πριν από 6 μέρες
source : Euraxess

The mitotic spindle is a microtubule-based apparatus that is responsible

for accurate segregation of the genetic material into two daughter

cells during mitotic cell division. Defects in spindle formation can

lead to aneuploidy, chromosomal instability or improper daughter

cell-size, which are associated with tumorigenesis or developmental

defects. However, the molecular mechanisms of spindle assembly are

incompletely understood. In our lab, we have found novel proteins and

novel phosphorylation sites on tubulin, which are essential for optimal

density and efficient polymerization of spindle microtubules in human

cells. Using state of the art methodologies such as replacement of

endogenous proteins and in vitro reconstitution in combination with high

resolution confocal microscopy, biochemistry analysis and live-cell

imaging, we will further investigate the role of these novel proteins

and phosphorylation sites we have discovered and their significance for

cancer cell proliferation and survival.

This job is for one post-doc, for 12 months, with a possibility for a

Offer Requirements

  • REQUIRED EDUCATION LEVEL Biological sciences : PhD or equivalent
  • BSc in Biology

    PhD in Molecular or Cell Biology or Biochemistry

    Good knowledge of confocal microscopy and eukaryotic cell culture

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